Abstract
Seventy-two patients suffering from a metastatic colorectal cancer received, as first line treatment, a combination chronotherapy with 5-FU and folinic acid (infused from 10 pm to 10 am with a peak at 4 am, respectively at doses of 700 and 300 mg/m2 per day) and carboplatin (infused at the dose of 40 mg/m2 per day from 10 am to 10 pm with a peak at 4 pm). The courses of four days were repeated every two weeks. A major tumoral response was observed in 60% cases (68% in those not previously treated with adjuvant chemotherapy). The median times to progression and overall survival established at 11 and 27 months. The clinical (grades 3-4 in maximum 5% cases) and hematological (grades 3-4 in maximum 10-29% cases) toxicities were quite limited. Our observations suggest the interest to incorporate carboplatin in the combined infusional treatment of colorectal cancer.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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English Abstract
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / toxicity
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Carboplatin / administration & dosage*
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Carboplatin / toxicity
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Chronobiology Phenomena*
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / mortality
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Colonic Neoplasms / pathology
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / mortality
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Colorectal Neoplasms / pathology
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Fluorouracil / administration & dosage*
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Fluorouracil / toxicity
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Humans
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Infusions, Intravenous
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Leucovorin / administration & dosage
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Male
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Middle Aged
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Neoplasm Metastasis
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Rectal Neoplasms / drug therapy
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Rectal Neoplasms / mortality
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Rectal Neoplasms / pathology
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Survival Analysis
Substances
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Carboplatin
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Leucovorin
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Fluorouracil