Chemical library synthesis using convergent approaches

Aaron B Beeler; Scott E Schaus; John A Porco Jr

doi:10.1016/j.cbpa.2005.04.005

Chemical library synthesis using convergent approaches

Curr Opin Chem Biol. 2005 Jun;9(3):277-84. doi: 10.1016/j.cbpa.2005.04.005.

Authors

Aaron B Beeler¹, Scott E Schaus, John A Porco Jr

Affiliation

¹ Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

PMID: 15939329
DOI: 10.1016/j.cbpa.2005.04.005

Abstract

New strategies are continuously being developed in combinatorial and diversity-oriented synthesis. Convergent design in target-oriented synthesis is commonly employed for construction of complex molecules. In this mini-review, we describe examples of convergent library design and synthesis as well as potential areas for future development.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Combinatorial Chemistry Techniques*
Drug Design*
Models, Chemical
Molecular Structure
Pharmaceutical Preparations / chemical synthesis*
Pharmaceutical Preparations / chemistry

Substances

Pharmaceutical Preparations

Grants and funding

P50 GM067041/GM/NIGMS NIH HHS/United States