Aim: Eosinophilic granulomas are benign localized lesions in the stomach that are distinct from eosinophilic gastritis. The aim of this study was to identify the potential etiological factors and clinical features of gastric eosinophilic granulomas (GEG).
Methods: Clinical manifestations, histopathological features, diagnosis and treatments of 48 hospitalized cases of GEG were analyzed retrospectively. A modified Giemsa staining was employed to detect Helicobacter pylori in 23 of these 48 patients.
Results: There was a significant gender difference among patients with GEG with male patients significantly more affected than female patients. The final diagnosis was made after operating the patients (the misdiagnosis level was rather high before resection). Lymphoid follicles were found in 68.6% of the tissues surrounding the lesion. H. pylori infection was detected in 69.6% of patients. In 11 patients eosinophilia in the peripheral blood was observed.
Conclusion: The results suggest that H. pylori infection, estrogen status and local allergic reactions may be associated with the development of GEG.