Abstract
Rhodinosyl transferase gene lndGT4, governing the conversion of the disaccharide oligoketide ('polyketide') landomycin D into a trisaccharide derivative landomycin E, was deleted in Streptomyces globisporus 1912 genome. Possible resistance mechanisms that protect the resulting landomycin D-producing mutant strain S. globisporus LD3 against the toxic action of landomycins were determined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / biosynthesis*
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Aminoglycosides / genetics
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / pharmacology
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Drug Resistance, Bacterial
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Gene Deletion
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Genes, Bacterial
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Genetic Complementation Test
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Glycosylation
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Streptomyces / genetics*
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Streptomyces / metabolism*
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Transferases / genetics
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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landomycin D
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landomycin E
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Transferases