Abstract
A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.
Publication types
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies / drug effects
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Antibodies / immunology
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Botulinum Toxins, Type A / administration & dosage*
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Botulinum Toxins, Type A / adverse effects
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Botulinum Toxins, Type A / chemistry
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Disability Evaluation
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Resistance / immunology
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Humans
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Muscle Contraction / drug effects
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Muscle Contraction / physiology
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Neck Muscles / drug effects
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Neck Muscles / physiopathology
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Torticollis / drug therapy*
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Torticollis / physiopathology
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Treatment Outcome
Substances
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Antibodies
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Botulinum Toxins, Type A
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incobotulinumtoxinA