Abstract
Rifampin-resistant meningococcal disease occurred in a child who had completed rifampin chemoprophylaxis for exposure to a sibling with meningococcemia. Susceptibility testing of 331 case isolates found only 1 other case of rifampin-resistant disease in Minnesota, USA, during 11 years of statewide surveillance. Point mutations in the RNA polymerase Beta subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / drug therapy
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Bacteremia / microbiology*
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Child
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DNA-Directed RNA Polymerases / genetics
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Drug Resistance, Bacterial* / genetics
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Female
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Humans
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Infant
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Male
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Meningococcal Infections / drug therapy
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Meningococcal Infections / microbiology*
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Microbial Sensitivity Tests
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Minnesota
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Neisseria meningitidis / drug effects*
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Neisseria meningitidis / isolation & purification
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Point Mutation
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Population Surveillance
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Rifampin / pharmacology*
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Rifampin / therapeutic use
Substances
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Anti-Bacterial Agents
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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Rifampin