Abstract
H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
CD8-Positive T-Lymphocytes / immunology*
-
Cross Reactions
-
Epitopes
-
Histocompatibility Antigens Class I / immunology*
-
Listeria monocytogenes / immunology*
-
Mice
-
Mice, Inbred C57BL
-
N-Formylmethionine / immunology*
Substances
-
Epitopes
-
H2-M3 antigen
-
Histocompatibility Antigens Class I
-
N-Formylmethionine