Abstract
Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Child
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Child, Preschool
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Drug Resistance, Bacterial*
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Female
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Haemophilus Infections / epidemiology*
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Haemophilus Infections / microbiology
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Haemophilus influenzae / classification
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Haemophilus influenzae / drug effects*
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Haemophilus influenzae / isolation & purification
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Haemophilus influenzae type b / drug effects
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Haemophilus influenzae type b / isolation & purification
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Hospitalization*
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Humans
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Infant
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Kenya
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Male
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Meningitis, Haemophilus / epidemiology
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Meningitis, Haemophilus / microbiology
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Microbial Sensitivity Tests
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Pneumonia, Bacterial / epidemiology
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Pneumonia, Bacterial / microbiology