Abstract
Eighty-five extended-spectrum beta-lactamase-producing Enterobacteriaceae from a Slovak hospital have been studied. SHV-2a was predominant, but other variants have been detected, namely, SHV-5, SHV-12, TEM-12, TEM-15, and TEM-132, which differed from TEM-1 by amino acid substitutions R164H, E240K, and I173V and had kinetic properties similar to those of TEM-28.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology
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Hospitals*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Sequence Analysis, DNA
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Slovakia / epidemiology
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beta-Lactam Resistance
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-lactamase SHV-2
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beta-Lactamases