Heterogeneity of genotype-phenotype correlation among macrolide-resistant Streptococcus agalactiae isolates

Antimicrob Agents Chemother. 2005 Jul;49(7):3080-2. doi: 10.1128/AAC.49.7.3080-3082.2005.

Abstract

Seventy-four erythromycin-resistant group B Streptococcus isolates were analyzed regarding their phenotype-genotype and phenotype-serotype correlation. Four different phenotypes were assessed, one of them for the first time. ermB and ermTR were the most frequent genotypes (80%). The most prevalent serotype III showed great phenotypic variability while serotype V was strongly associated only with two different phenotypes.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Drug Resistance, Bacterial / genetics*
  • Erythromycin / pharmacology*
  • Genotype
  • Humans
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests / methods
  • Phenotype
  • Serotyping
  • Streptococcus agalactiae / classification*
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Macrolides
  • Erythromycin