Cooperative uptake of microcin E492 by receptors FepA, Fiu, and Cir and inhibition by the siderophore enterochelin and its dimeric and trimeric hydrolysis products

Erwin Strahsburger; Marcelo Baeza; Octavio Monasterio; Rosalba Lagos

doi:10.1128/AAC.49.7.3083-3086.2005

Cooperative uptake of microcin E492 by receptors FepA, Fiu, and Cir and inhibition by the siderophore enterochelin and its dimeric and trimeric hydrolysis products

Antimicrob Agents Chemother. 2005 Jul;49(7):3083-6. doi: 10.1128/AAC.49.7.3083-3086.2005.

Authors

Erwin Strahsburger¹, Marcelo Baeza, Octavio Monasterio, Rosalba Lagos

Affiliation

¹ Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

Abstract

Microcin E492 uptake by FepA, Fiu, and Cir is cooperative, with FepA being the main receptor. No TonB-mediated interaction with the ferric catecholate receptors is needed for microcin to exert action at the cytoplasmic membrane. Microcin E492 uptake by the receptors is inhibited by the dimer and trimer of dihydroxybenzoylserine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / metabolism
Bacterial Outer Membrane Proteins / metabolism*
Bacteriocins / metabolism*
Carrier Proteins / metabolism
Dimerization
Enterobactin / metabolism*
Hydrolysis
Peptides
Receptors, Cell Surface / metabolism*
Siderophores / metabolism*

Substances

Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Bacteriocins
Carrier Proteins
Peptides
Receptors, Cell Surface
Siderophores
enterobactin receptor
siderophore receptors
microcin
Enterobactin