Abstract
New antibiotic polyketides, named aurafuron A (1) and B (2) were isolated from culture extracts of myxobacteria of the species Stigmatella aurantiaca and Archangium gephyra, strain Ar 10844. By multi-step chromatography 1 and 2 were separated from a variety of other non-related co-metabolites, and their structures elucidated by spectroscopic methods as new 5-alkenyl-3 3(2H)-furanones. Aurafurons inhibited the growth of some filamentous fungi and additionally, aurafuron B was weakly active against few Gram-positive bacteria. Both compounds also showed cytotoxic activity against the mouse fibroblast cell line L929.
MeSH terms
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Animals
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Anti-Bacterial Agents / metabolism*
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / biosynthesis
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacology
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Bacteria / drug effects
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Culture Media
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Fermentation
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Furans / analysis
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Furans / metabolism*
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Furans / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Microbial Sensitivity Tests
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Myxococcales / metabolism*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Stigmatella / metabolism*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Culture Media
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Furans
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aurafuron A
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aurafuron B