Subcortical loops through the basal ganglia

Trends Neurosci. 2005 Aug;28(8):401-7. doi: 10.1016/j.tins.2005.06.006.

Abstract

Parallel, largely segregated, closed-loop projections are an important component of cortical-basal ganglia-cortical connectional architecture. Here, we present the hypothesis that such loops involving the neocortex are neither novel nor the first evolutionary example of closed-loop architecture involving the basal ganglia. Specifically, we propose that a phylogenetically older, closed-loop series of subcortical connections exists between the basal ganglia and brainstem sensorimotor structures, a good example of which is the midbrain superior colliculus. Insofar as this organization represents a general feature of brain architecture, cortical and subcortical inputs to the basal ganglia might act independently, co-operatively or competitively to influence the mechanisms of action selection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basal Ganglia / anatomy & histology*
  • Basal Ganglia / metabolism
  • Brain Mapping
  • Cerebral Cortex / anatomy & histology*
  • Cerebral Cortex / metabolism
  • Cholera Toxin / metabolism
  • Humans
  • Nerve Net / anatomy & histology*
  • Nerve Net / metabolism
  • Neural Pathways / anatomy & histology
  • Neural Pathways / metabolism
  • Substantia Nigra / anatomy & histology
  • Substantia Nigra / metabolism

Substances

  • Cholera Toxin