The analysis of the results of the detection, diagnosis, and recording of patients with active tuberculosis in an investigatory solitary cells of the Department of Penitentiary Facilities, Ministry of Justice of the Republic of Moldova, has revealed significant features that greatly differ not only from such a direction of work in the health care facilities, but also from other institutions (penal colonies, settlements) of this system. These features are associated with the specificity of the working conditions of investigatory solitary cells and mainly with the constant change of this contingent.