Abstract
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. Gamma-hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Esterases / metabolism*
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Hydrolysis
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Hydroxylamines / chemistry*
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Hydroxylamines / metabolism*
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Hydroxylation
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Lactones / chemistry
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Lactones / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Prodrugs / metabolism*
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Structure-Activity Relationship
Substances
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Hydroxylamines
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Lactones
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Prodrugs
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Esterases