Accelerating bacterial identification by infrared spectroscopy by employing microarray deposition of microorganisms

Foodborne Pathog Dis. 2004 Fall;1(3):172-7. doi: 10.1089/fpd.2004.1.172.

Abstract

A microarray method for the deposition of bacteria onto an agar slide was developed to accelerate the formation of microcolonies. Representative microarrays each consisting of 40 micro-spots of five replicates of eight foodborne bacteria (Yersinia enterocolitica, Staphylococcus aureus, Salmonella typhimurium, Listeria monocytogenes, Enterobacter cloacae, Citrobacter freundii, Klebsiella pneumoniae, and Escherichia coli) were printed on a Brain Heart Infusion (BHI) agar slide using a contact micro-spotting robotic system. Within 3 h, sufficient bacterial cells were obtained to allow accurate identification of the microorganism by infrared spectroscopy. This approach allows a "complete-in-a-single-day" analysis of a large array of samples.

MeSH terms

  • Bacteria / isolation & purification*
  • Citrobacter freundii / isolation & purification
  • Cluster Analysis
  • Enterobacter cloacae / isolation & purification
  • Escherichia coli / isolation & purification
  • Food Microbiology*
  • Klebsiella pneumoniae / isolation & purification
  • Listeria monocytogenes / isolation & purification
  • Microarray Analysis / methods*
  • Salmonella typhimurium / isolation & purification
  • Sensitivity and Specificity
  • Species Specificity
  • Spectroscopy, Fourier Transform Infrared / methods*
  • Staphylococcus aureus / isolation & purification
  • Time Factors
  • Yersinia enterocolitica / isolation & purification