Delayed onset bleomycin-induced pneumonitis

Urology. 2005 Jul;66(1):195. doi: 10.1016/j.urology.2005.01.038.

Abstract

We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer. Bleomycin sometimes causes fatal pulmonary toxicity, including bleomycin-induced pneumonitis. The central event in the development of pneumonitis is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals. Pulmonary toxicity usually begins at bleomycin administration. The development of bleomycin-induced pneumonitis up to 6 months after bleomycin therapy has also been reported. We report a patient who developed bleomycin-induced pneumonitis 2 years after the initiation of bleomycin-containing chemotherapy regimens.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibiotics, Antineoplastic / adverse effects*
  • Bleomycin / adverse effects*
  • Humans
  • Male
  • Pneumonia / chemically induced*
  • Testicular Neoplasms / drug therapy
  • Time Factors

Substances

  • Antibiotics, Antineoplastic
  • Bleomycin