Abstract
Synthesis and biological characterization of a series of alpha-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Atherosclerosis / prevention & control*
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Humans
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Nitric Oxide / chemistry*
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Nitric Oxide Donors / chemical synthesis*
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Nitric Oxide Donors / chemistry
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Nitric Oxide Donors / pharmacology*
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Rats
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Rats, Wistar
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Spectrophotometry, Infrared
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Tocopherols / chemical synthesis*
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Tocopherols / chemistry
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Tocopherols / pharmacology*
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Vasodilator Agents / chemical synthesis
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Vasodilator Agents / chemistry
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Vasodilator Agents / pharmacology
Substances
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Antioxidants
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Nitric Oxide Donors
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Vasodilator Agents
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Nitric Oxide
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Tocopherols