A 50-year-old man was urgently transferred to another hospital due to unconsciousness diagnosed as due to primary pulmonary hypertension following cardiac catheter test and pulmonary blood flow scintigraphy. He was referred to our hospital for treatment of hypoxemia. Thereafter, he was treated by home oxygen therapy and home epoprostenol therapy, although he required frequent admissions. During treatment, problems consisting of self-evulsion and infection of the insertion site occurred. Changes in symptoms, arterial blood gas analysis, serum BNP and ultracardiography were useful for managing home epoprostenol therapy. We reported a case of primary pulmonary hypertension treated by long-term continuous administration of epoprostenol for about 6 years and 9 months.