Abstract
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Crystallography, X-Ray
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DNA / metabolism*
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Drug Screening Assays, Antitumor
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Intercalating Agents / chemical synthesis*
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Intercalating Agents / chemistry
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Intercalating Agents / pharmacology
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Phenanthridines / chemical synthesis*
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Phenanthridines / chemistry
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Phenanthridines / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Imidazoles
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Intercalating Agents
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Phenanthridines
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phenanthridinium
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DNA