Abstract
Neurosteroids administered during the neonatal period affect the development of several brain systems. We examined the effects of neonatal treatment with pregnenolone and dehydroepiandrosterone (DHEA) on a marker of neuronal dendrites, microtubule-associated protein 2 (MAP-2), in rat brain. Neonatal treatment with pregnenolone and DHEA increased the expression of MAP-2 in the hippocampus and nucleus accumbens but not in the prefrontal cortex, striatum or amygdala in adulthood.
MeSH terms
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Animals
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Animals, Newborn
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Biomarkers / metabolism
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Brain / drug effects
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Brain / growth & development*
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Brain / metabolism
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Dehydroepiandrosterone / pharmacology*
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Dendrites / drug effects
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Dendrites / metabolism*
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Dendrites / ultrastructure
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Female
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Hippocampus / drug effects
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Hippocampus / growth & development
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Hippocampus / metabolism
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Male
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Microtubule-Associated Proteins / drug effects
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Microtubule-Associated Proteins / metabolism*
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Neural Pathways / drug effects
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Neural Pathways / growth & development*
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Neural Pathways / metabolism
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / growth & development
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Nucleus Accumbens / metabolism
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Pregnenolone / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Up-Regulation / drug effects
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Up-Regulation / physiology
Substances
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Biomarkers
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MAP2 protein, rat
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Microtubule-Associated Proteins
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Dehydroepiandrosterone
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Pregnenolone