Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anilides / administration & dosage
  • Anilides / chemistry
  • Anilides / pharmacology*
  • Animals
  • Antimalarials / administration & dosage
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Binding Sites
  • Enzyme Inhibitors / administration & dosage
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Farnesyltranstransferase / antagonists & inhibitors*
  • Liver / drug effects
  • Microsomes / drug effects
  • Microsomes / metabolism
  • Models, Molecular
  • Molecular Structure
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / growth & development*
  • Rats
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Anilides
  • Antimalarials
  • Enzyme Inhibitors
  • Farnesyltranstransferase