Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions

Org Lett. 2005 Jul 21;7(15):3183-6. doi: 10.1021/ol050852+.

Abstract

[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.