Subtyping obsessive-compulsive disorder: clinical and immunological findings in child and adult onset

J Psychiatr Res. 2006 Apr;40(3):207-13. doi: 10.1016/j.jpsychires.2005.04.003. Epub 2005 Jul 14.

Abstract

It has been suggested that certain kinds of childhood OCD with specific clinical, biological and immunological characteristics may form a subgroup of OCD. We study the presence of these characteristics in child onset OCD and propose that the disorder be considered as a subtype of adult OCD. Forty adult patients with OCD were divided in two groups according to time of disease onset: 18 early onset and 21 late. Both sets were compared with a control group of 14 psychiatric patients. Child onset OCD was associated with higher mean ASLO titers, higher frequencies of history of tic disorders and tonsillitis in childhood and compulsive symptoms. No differences were found in D8/17 antibody titers or in other autoimmune parameters. The findings suggest that child onset OCD can be considered as a subgroup of adult OCD, although more specific biological markers are needed to identify it.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Monoclonal / immunology*
  • Autoantibodies / immunology
  • CD8 Antigens / immunology*
  • Child
  • Female
  • Humans
  • Immunoglobulin M / immunology*
  • Male
  • Obsessive-Compulsive Disorder* / classification
  • Obsessive-Compulsive Disorder* / immunology
  • Obsessive-Compulsive Disorder* / psychology

Substances

  • Antibodies, Monoclonal
  • Autoantibodies
  • CD8 Antigens
  • Immunoglobulin M