Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription

V S Simonova; A V Samusenko; N A Filippova; A N Tevyashova; L S Lyniv; G I Kulik; V F Chekhun; A A Shtil

doi:10.1007/s10517-005-0321-3

Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription

Bull Exp Biol Med. 2005 Apr;139(4):455-9. doi: 10.1007/s10517-005-0321-3.

Authors

V S Simonova¹, A V Samusenko, N A Filippova, A N Tevyashova, L S Lyniv, G I Kulik, V F Chekhun, A A Shtil

Affiliation

¹ Institute of Carcinogenesis, N. N. Blokhin Oncological Research Center, Russian Academy of Medical Sciences, Russia.

PMID: 16027880
DOI: 10.1007/s10517-005-0321-3

Abstract

Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription.

MeSH terms

Antibiotics, Antineoplastic / pharmacology*
Apoptosis / drug effects*
Carbohydrate Conformation
Cell Line, Tumor
Humans
Molecular Sequence Data
Olivomycins / chemistry
Olivomycins / pharmacology*
Transcription, Genetic / physiology*
Tumor Suppressor Protein p53 / physiology*

Substances

Antibiotics, Antineoplastic
Tumor Suppressor Protein p53
Olivomycins