Abstract
The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interfering with CTL generation and localization in the tumor mass.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antibodies, Monoclonal / immunology*
-
Leukemia, Experimental / immunology*
-
Lymphocyte Function-Associated Antigen-1 / immunology*
-
Lymphocytes, Tumor-Infiltrating / immunology*
-
Mice
-
Moloney murine leukemia virus*
-
Moloney murine sarcoma virus*
-
Sarcoma, Experimental / immunology*
Substances
-
Antibodies, Monoclonal
-
Lymphocyte Function-Associated Antigen-1