The authors treat 15 women with recurrent vulvovaginal candidosis with 3 sequential oral 150-mg doses of fluconazole (Mycosys, Gedeon Richter), each dose administered 72 hours after the first dose. Candida albicans was isolated in 14 women and Candida glabrata--in one. 14 days later all women had no clinical signs of vulvovaginal candidosis. Three months after the treatment only 11 women consulted for a checking exam--and all of them without clinical complaints, though in three of them (73.3%) C. albicans was isolated from the vaginal discharge. The authors discuss the difficulties in the treatment of recurrent vulvovaginal candidosis and the advantages of the sequential type of therapy with fluconazole.