Serratia marcescens prosthesis infection successfully treated with meropenem after imipenem failure

J Infect. 2005 Aug;51(2):E45-7. doi: 10.1016/j.jinf.2004.08.013.

Abstract

A 78-year-old woman developed an early knee-prosthesis infection due to multiresistant Serratia marcescens that was successfully treated with high-dose meropenem, after failure of a long-term therapy combining imipenem and multiple surgical interventions. Because of its lower neurotoxicity, meropenem might be preferred to imipenem/cilastatin for the treatment of osteo-articular infections due to multiresistant Gram-negative bacilli in the elderly.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amikacin / therapeutic use
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Arthroplasty, Replacement, Knee / adverse effects
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Imipenem / therapeutic use
  • Knee Prosthesis / microbiology*
  • Meropenem
  • Prosthesis-Related Infections / diagnosis
  • Prosthesis-Related Infections / drug therapy*
  • Prosthesis-Related Infections / microbiology
  • Serratia Infections / diagnosis
  • Serratia Infections / drug therapy*
  • Serratia Infections / microbiology
  • Serratia marcescens / drug effects*
  • Serratia marcescens / isolation & purification*
  • Thienamycins / therapeutic use
  • Treatment Failure
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • Imipenem
  • Amikacin
  • Meropenem