Abstract
We investigated whether gender differences in renal damage in DOCA-salt hypertension are associated with effects of ovarian hormones and/or endothelin-1 (ET-1). Renal injuries and renal pre-pro-ET-1 mRNA expression were enhanced in male and female ovariectomized (OVX) DOCA rats versus female DOCA rats. Treatment with estrogen plus progesterone or progesterone, but not estrogen alone, attenuated renal damage and pre-pro-ET-1 mRNA expression in OVX DOCA rats. The ETA antagonist BMS182874 greatly ameliorated renal damage in male and OVX DOCA rats. In conclusion, the ovarian hormones have a protective role on the renal structural alterations in female DOCA rats by modulating effects of ET-1, via ETA receptors.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dansyl Compounds / pharmacology
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Desoxycorticosterone / antagonists & inhibitors
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Desoxycorticosterone / chemistry
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Disease Models, Animal
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Endothelin-1 / genetics
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Endothelin-1 / pharmacology*
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Estrogens / pharmacology
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Female
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Hydralazine / pharmacology
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Hypertension / chemically induced
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Hypertension / physiopathology
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Hypertension / prevention & control
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Kidney / chemistry
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Kidney / drug effects*
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Kidney / physiopathology
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Kidney Diseases / chemically induced
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Kidney Diseases / physiopathology
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Kidney Diseases / prevention & control*
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Male
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Ovariectomy / methods
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Progesterone / pharmacology
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RNA, Messenger / genetics
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Rats
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Rats, Wistar
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Receptor, Endothelin A / drug effects
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Sex Characteristics*
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Sodium Chloride
Substances
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Dansyl Compounds
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Endothelin-1
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Estrogens
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RNA, Messenger
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Receptor, Endothelin A
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5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
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Hydralazine
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Desoxycorticosterone
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Sodium Chloride
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Progesterone