Abstract
Dysesthesia, allodynia, distal muscle weakness, and sensory impairment were noted in two patients with acute thallium intoxication. Two months later, nerve conduction studies showed an axonal degeneration. Sural nerve biopsy disclosed a decreased fiber density in the large myelinated fibers. Quantitative sensory testing also revealed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy confirmed a loss of epidermal nerves indicating an involvement of the small sensory nerves.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Biopsy
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Environmental Exposure*
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Female
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Humans
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Hyperalgesia / chemically induced
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Hyperalgesia / pathology
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Hyperalgesia / physiopathology
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Male
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Middle Aged
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Motor Neurons / drug effects
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Motor Neurons / pathology
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Muscle Weakness / chemically induced
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Muscle Weakness / pathology
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Muscle Weakness / physiopathology
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Nerve Fibers, Myelinated / drug effects
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Nerve Fibers, Myelinated / pathology
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Nerve Fibers, Unmyelinated / drug effects
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Nerve Fibers, Unmyelinated / pathology
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Neural Conduction / drug effects
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Neural Conduction / physiology
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Neuralgia / chemically induced*
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Neuralgia / pathology
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Neuralgia / physiopathology
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Neurons, Afferent / drug effects
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Neurons, Afferent / pathology
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Nociceptors / drug effects
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Nociceptors / pathology
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Peripheral Nerves / drug effects*
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Peripheral Nerves / pathology
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Peripheral Nerves / physiopathology
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Peripheral Nervous System Diseases / chemically induced*
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Peripheral Nervous System Diseases / pathology
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Peripheral Nervous System Diseases / physiopathology
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Somatosensory Disorders / chemically induced
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Somatosensory Disorders / pathology
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Somatosensory Disorders / physiopathology
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Sural Nerve / drug effects
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Sural Nerve / pathology
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Sural Nerve / physiopathology
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Thallium / poisoning*