Abstract
A Pseudomonas aeruginosa strain expresses an extended-spectrum beta-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The bla(GES-9) gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Aztreonam / metabolism
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Aztreonam / pharmacology*
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Base Sequence
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DNA Transposable Elements / genetics
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Humans
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Integrons*
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Kinetics
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics
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beta-Lactam Resistance*
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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DNA Transposable Elements
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beta-Lactamases
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Aztreonam