Abstract
Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Leukemia Virus, Murine / genetics
-
Leukemia Virus, Murine / immunology*
-
Leukemia, Experimental / genetics
-
Leukemia, Experimental / immunology*
-
Leukemia, Experimental / pathology
-
Lymphoma, T-Cell / genetics
-
Lymphoma, T-Cell / immunology
-
Lymphoma, T-Cell / pathology
-
Mice
-
Mice, Inbred BALB C
-
NFATC Transcription Factors / deficiency
-
NFATC Transcription Factors / genetics
-
NFATC Transcription Factors / immunology*
-
Retroviridae Infections / genetics
-
Retroviridae Infections / immunology*
-
Retroviridae Infections / pathology
-
Tumor Suppressor Proteins / genetics
-
Tumor Suppressor Proteins / immunology*
-
Tumor Virus Infections / genetics
-
Tumor Virus Infections / immunology*
-
Tumor Virus Infections / pathology
-
Virus Integration / immunology
Substances
-
NFATC Transcription Factors
-
Nfatc3 protein, mouse
-
Tumor Suppressor Proteins