MEN signaling: daughter bound pole must escape her mother to be fully active

Dev Cell. 2005 Aug;9(2):168-70. doi: 10.1016/j.devcel.2005.07.006.

Abstract

Budding yeast divide asymmetrically and must therefore align the position of the mitotic spindle with the plane of division. The success of this process is monitored by a checkpoint-signaling mechanism. Two recent papers in Molecular Cell reveal an important new facet of this signal transduction pathway.

MeSH terms

  • Cell Cycle Proteins / metabolism
  • Cytokinesis / physiology*
  • Cytoskeletal Proteins / metabolism
  • Guanine Nucleotide Exchange Factors / metabolism
  • Monomeric GTP-Binding Proteins / metabolism
  • Protein Kinases / metabolism
  • Protein Serine-Threonine Kinases
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction / physiology*
  • Spindle Apparatus / physiology*

Substances

  • BFA1 protein, S cerevisiae
  • BUB2 protein, S cerevisiae
  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • Guanine Nucleotide Exchange Factors
  • LTE1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • TEM1 protein, S cerevisiae
  • Protein Kinases
  • KIN4 kinase, S cerevisiae
  • Protein Serine-Threonine Kinases
  • Monomeric GTP-Binding Proteins