Abstract
The transcription factor NF-kappaB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-kappaB pathway: degradation of IkappaB (inhibitor of NF-kappaB), processing of NF-kappaB precursors, and activation of the IkappaB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Humans
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I-kappa B Kinase
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I-kappa B Proteins / metabolism
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JNK Mitogen-Activated Protein Kinases / metabolism
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Lymphocyte Activation / physiology
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MAP Kinase Kinase 4
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MAP Kinase Kinase Kinases / metabolism
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Mitogen-Activated Protein Kinase Kinases / metabolism
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Models, Biological
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NF-kappa B / metabolism*
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Protein Kinases / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Signal Transduction / physiology*
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TNF Receptor-Associated Factor 2 / metabolism
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TNF Receptor-Associated Factor 6 / metabolism
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Ubiquitin / metabolism
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Ubiquitin / physiology*
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Ubiquitin-Protein Ligases / metabolism
Substances
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I kappa B beta protein
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I-kappa B Proteins
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NF-kappa B
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TNF Receptor-Associated Factor 2
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TNF Receptor-Associated Factor 6
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Ubiquitin
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Ubiquitin-Protein Ligases
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Protein Kinases
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Protein Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human
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JNK Mitogen-Activated Protein Kinases
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MAP Kinase Kinase Kinases
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MAP kinase kinase kinase 7
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MAP Kinase Kinase 4
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Mitogen-Activated Protein Kinase Kinases