Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica

Christina Bruntner; Tatiana Binder; Wasu Pathom-aree; Michael Goodfellow; Alan T Bull; Olivier Potterat; Carsten Puder; Stefan Hörer; Angela Schmid; Walter Bolek; Klaus Wagner; Gerhard Mihm; Hans-Peter Fiedler

doi:10.1038/ja.2005.43

Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica

J Antibiot (Tokyo). 2005 May;58(5):346-9. doi: 10.1038/ja.2005.43.

Authors

Christina Bruntner¹, Tatiana Binder, Wasu Pathom-aree, Michael Goodfellow, Alan T Bull, Olivier Potterat, Carsten Puder, Stefan Hörer, Angela Schmid, Walter Bolek, Klaus Wagner, Gerhard Mihm, Hans-Peter Fiedler

Affiliation

¹ Mikrobiologisches Institut, Universität Tübingen, au der Morgenstelle 28, D-72076 Tübingen, Germany.

PMID: 16060387
DOI: 10.1038/ja.2005.43

Abstract

A new angucyclinone antibiotic, frigocyclinone, was isolated from Streptomyces griseus strain NTK 97, consisting of a tetrangomycin moiety attached through a C-glycosidic linkage with the aminodeoxysugar ossamine. Frigocyclinone showed antibacterial activities against Gram-positive bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antarctic Regions
Anthraquinones / isolation & purification
Anthraquinones / metabolism
Anthraquinones / pharmacology*
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Fermentation
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Models, Molecular
Spectrophotometry, Ultraviolet
Streptomyces griseus / metabolism*

Substances

Anthraquinones
Anti-Bacterial Agents
frigocyclinone