Lentigo maligna. Cytogenetic, ultrastructural, and phenotypic characterization of a primary cell culture

P Grammatico; A Modesti; K Steindl; S Scarpa; A Heouaine; M Picardo; G Del Porto

doi:10.1016/0165-4608(92)90006-t

Lentigo maligna. Cytogenetic, ultrastructural, and phenotypic characterization of a primary cell culture

Cancer Genet Cytogenet. 1992 Jun;60(2):141-6. doi: 10.1016/0165-4608(92)90006-t.

Authors

P Grammatico¹, A Modesti, K Steindl, S Scarpa, A Heouaine, M Picardo, G Del Porto

Affiliation

¹ Dipartimento di Medicina Sperimentale, Università degli Studi di Roma La Sapienza, Italy.

PMID: 1606557
DOI: 10.1016/0165-4608(92)90006-t

Abstract

Lentigo maligna is an early cutaneous neoplastic lesion. This article presents the cytogenetic, ultrastructural, and phenotypic characterization of a primary cell culture obtained from a patient affected with lentigo maligna. Two cellular clones were identified, both characterized by chromosomal markers involving chromosome 10 with a breakpoint at 10q26.

Publication types

Case Reports

MeSH terms

Chromosome Deletion*
Chromosomes, Human, Pair 10*
Fluorescent Antibody Technique
Humans
Lentigo / genetics*
Lentigo / pathology
Male
Melanocytes / pathology
Melanoma / genetics*
Melanoma / pathology
Microscopy, Electron
Middle Aged
Skin Neoplasms / genetics*
Skin Neoplasms / pathology
Translocation, Genetic / genetics*
Tumor Cells, Cultured
Vimentin / analysis

Substances

Vimentin