Conventional single-photon detectors at communication wavelengths suffer from low quantum efficiencies and large dark counts. We present a single-photon detection system, operating at communication wavelengths, based on guided-wave frequency upconversion in a nonlinear crystal with an overall system detection efficiency (upconversion + detection) exceeding 46% at 1.56 microm. This system consists of a fiber-pigtailed reverse-proton-exchanged periodically poled LiNbO3 waveguide device in conjunction with a silicon-based single-photon counting module.