Abstract
A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and micro-positron emission tomography (micro-PET) imaging experiments in rats. Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo.
MeSH terms
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Animals
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Brain / diagnostic imaging
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Brain / metabolism
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Carbon Radioisotopes
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Ligands
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Positron-Emission Tomography
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / pharmacology
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Rats
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Receptors, Metabotropic Glutamate / antagonists & inhibitors
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Receptors, Metabotropic Glutamate / metabolism*
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Structure-Activity Relationship
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Tissue Distribution
Substances
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(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate
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Carbon Radioisotopes
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Ligands
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Quinolines
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Radiopharmaceuticals
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Receptors, Metabotropic Glutamate
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metabotropic glutamate receptor type 1