Abstract
Cell suspension cultures of five plants (Catharanthus roseus, Ginkgo biloba, Platycodon grandiflorum, Taxus cuspidata, Phytolacca asinosa) were employed to bioconvert the eudesmanolide compound, alpha-santonin. Reactions occurring were hydroxylation (C-1, C-11 and C-15), reduction of the double bond [1(2) or 3(4)], rearrangment of the eudesmanolide skeleton to a guaianolide skeleton and lactone-ring hydrolysis. Four new compounds were identified.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Biotransformation
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Catharanthus / cytology
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Catharanthus / metabolism
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Cell Culture Techniques / methods
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Cells, Cultured
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Ginkgo biloba / cytology
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Ginkgo biloba / metabolism
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Molecular Structure
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Phytolacca / cytology
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Phytolacca / metabolism
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Plant Cells
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Plants / metabolism*
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Platycodon / cytology
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Platycodon / metabolism
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Santonin / chemistry
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Santonin / metabolism*
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Species Specificity
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Taxus / cytology
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Taxus / metabolism