Abstract
The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Dimerization
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Hepatitis C / enzymology*
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Inhibitory Concentration 50
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Oxidation-Reduction
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Pyridines / chemistry
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Serine Proteinase Inhibitors / chemical synthesis*
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Serine Proteinase Inhibitors / pharmacology
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Structure-Activity Relationship
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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Antiviral Agents
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NS3 protein, hepatitis C virus
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Pyridines
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Serine Proteinase Inhibitors
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Viral Nonstructural Proteins