Abstract
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis
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Anticonvulsants / chemistry*
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Anticonvulsants / pharmacology*
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Disease Models, Animal
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Drug Design
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Drug Evaluation, Preclinical
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In Vitro Techniques
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Mice
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Mice, Inbred DBA
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Molecular Structure
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Pregabalin
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Seizures / prevention & control*
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Stereoisomerism
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / chemical synthesis
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gamma-Aminobutyric Acid / chemistry
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gamma-Aminobutyric Acid / pharmacology
Substances
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Anticonvulsants
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Pregabalin
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gamma-Aminobutyric Acid