Venous thromboembolism and mortality after hip fracture surgery: the ESCORTE study

J Thromb Haemost. 2005 Sep;3(9):2006-14. doi: 10.1111/j.1538-7836.2005.01545.x.

Abstract

Background: Recent changes in the management of hip fracture surgery patients may have modified the epidemiology of postoperative complications.

Objectives: We performed an observational study of a cohort of patients undergoing hip fracture surgery to update the epidemiological data on this population. The primary study outcome was the incidence of confirmed symptomatic venous thromboembolism (VTE) [defined as deep vein thrombosis, pulmonary embolism (PE), or both] at 3 months. Overall mortality at 1, 3 and 6 months was also evaluated.

Patients/methods: Consecutive patients aged at least 18 years hospitalized in French public or private hospitals (531 centers) undergoing hip fracture surgery were recruited prospectively during 2 months in 2002 and a follow-up at 6 months. Predictive factors for VTE at 3 months and for death at 6 months were also analyzed.

Results: Data from 6860 (97.3%) of the 7019 recruited patients were included in the analysis. The median age was 82 years. Low molecular weight heparins were administered perioperatively in 97.6% of patients; 69.5% received this treatment for at least 4 weeks. The actuarial rate of confirmed symptomatic VTE at 3 months was 1.34% (85 events, 95% CI: 1.04-1.64). There were 16 PEs (actuarial rate: 0.25%), three of which were fatal. Overall, 1006 (14.7%) patients were dead at 6 months. Cardiovascular disease was the most frequent cause of death (270 patients; 26.8%).

Conclusions: The current rate of postoperative VTE is low, but overall mortality remains high. Indeed, hip fracture patients belong to a vulnerable group of old people with comorbid diseases and a high risk of postoperative morbidity and mortality. An interdisciplinary approach could be the challenge to improve short and long-term outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Follow-Up Studies
  • Hemorrhage / etiology
  • Hip Fractures / complications*
  • Hip Fractures / epidemiology
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Risk Factors
  • Survival Analysis
  • Thromboembolism / epidemiology
  • Thromboembolism / etiology
  • Thromboembolism / mortality*
  • Venous Thrombosis / epidemiology
  • Venous Thrombosis / etiology
  • Venous Thrombosis / mortality*