Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

Leukemia. 2005 Oct;19(10):1851-3. doi: 10.1038/sj.leu.2403919.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD34 / metabolism*
  • Benzamides
  • Chemotactic Factors / pharmacology*
  • Cytokines / pharmacology*
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
  • Lymphocytes / metabolism
  • Phosphatidylinositol Phosphates / metabolism*
  • Piperazines / therapeutic use*
  • Pyrimidines / therapeutic use*

Substances

  • Antigens, CD34
  • Benzamides
  • Chemotactic Factors
  • Cytokines
  • Phosphatidylinositol Phosphates
  • Piperazines
  • Pyrimidines
  • phosphatidylinositol 3,4,5-triphosphate
  • Imatinib Mesylate