Distal renal tubular acidosis: alkali heals osteomalacia and increases net production of 1,25-dihydroxyvitamin D

Nephron Physiol. 2005;101(3):p72-6. doi: 10.1159/000087537. Epub 2005 Aug 16.

Abstract

In 2 women with distal renal tubular acidosis and osteomalacia, alkali treatment cured the bone disease and was accompanied by marked increases in the serum 1,25 dihydroxyvitamin D concentration, without a significant change in the 25-hydroxyvitamin D concentration.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Renal Tubular / complications*
  • Acidosis, Renal Tubular / drug therapy*
  • Adult
  • Alkalies / administration & dosage*
  • Biopsy
  • Bone and Bones / pathology
  • Fatal Outcome
  • Female
  • Humans
  • Kidney Tubules, Distal / metabolism
  • Middle Aged
  • Myocardial Infarction
  • Osteomalacia / drug therapy*
  • Osteomalacia / etiology*
  • Osteomalacia / pathology
  • Vitamin D / analogs & derivatives*
  • Vitamin D / biosynthesis
  • Vitamin D / blood

Substances

  • Alkalies
  • Vitamin D
  • 1,25-dihydroxyvitamin D