Abstract
The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amination
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Catalysis
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Combinatorial Chemistry Techniques*
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Hydrocarbons, Halogenated / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Phosphines / chemistry
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Pyrimidines / chemistry
Substances
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Hydrocarbons, Halogenated
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Phosphines
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Pyrimidines
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Palladium