A cytotoxic sesquiterpene alkaloid from the South China Sea gorgonian Subergorgia suberosa

Shu-Hua Qi; Si Zhang; Xiang Li; Qing-Xin Li

doi:10.1021/np050105l

A cytotoxic sesquiterpene alkaloid from the South China Sea gorgonian Subergorgia suberosa

J Nat Prod. 2005 Aug;68(8):1288-9. doi: 10.1021/np050105l.

Authors

Shu-Hua Qi¹, Si Zhang, Xiang Li, Qing-Xin Li

Affiliation

¹ Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301 Guangdong, People's Republic of China. [email protected]

PMID: 16124781
DOI: 10.1021/np050105l

Abstract

A new sesquiterpene alkaloid, 6-(9'-purine-6',8'-diolyl)-2beta-suberosanone (1), together with three known sesquiterpenes, suberosenol A (2), subergorgic acid (3), and subergorgiol (4), was isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian Subergorgia suberosa. The structure of 1 was determined through spectroscopic methods. Compound 1 showed moderate cytotoxicity against the human breast carcinoma MDA-MB-231 cell line with an IC50 of 8.87 microg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Molecular Structure
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Tumor Cells, Cultured

Substances

6-(9'-purine-6',8'-diolyl)-2beta-suberosanone
Alkaloids
Antineoplastic Agents
Sesquiterpenes