Abstract
A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / classification
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Antiprotozoal Agents / pharmacology*
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Hydrogen / chemistry
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Leishmania / drug effects*
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Molecular Structure
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry*
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Pyrimidines / classification
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
Substances
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Antiprotozoal Agents
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Pyrimidines
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Hydrogen