Abstract
Embryonic-maternal signaling is vital to implantation. We have identified a cellular protein that indirectly regulates secretion of IL-1beta, a proinflammatory cytokine that is involved in this signaling process. Regeneration and tolerance factor is a V-ATPase protein that regulates ATP levels in a variety of cells including macrophages, which, in turn, regulates the P2X7 ligand-gated ion channel. As extracellular levels of ATP rise, the P2X7 receptor undergoes a change in permeability, which leads to the onset of apoptotic events and the release of IL-1beta. IL-1beta leads to local inflammation and vascularization, which is integral to establishing a successful implantation site.
MeSH terms
-
Animals
-
Apoptosis
-
Female
-
Humans
-
Interleukin-1 / genetics
-
Interleukin-1 / metabolism
-
Lymphocyte Activation
-
Maternal-Fetal Exchange / immunology
-
Maternal-Fetal Exchange / physiology
-
Mice
-
Pregnancy
-
Receptors, Purinergic P2 / immunology
-
Receptors, Purinergic P2 / metabolism
-
Receptors, Purinergic P2X7
-
Suppressor Factors, Immunologic / genetics
-
Suppressor Factors, Immunologic / metabolism*
-
T-Lymphocytes / immunology
-
T-Lymphocytes / metabolism
-
Vacuolar Proton-Translocating ATPases / immunology*
-
Vacuolar Proton-Translocating ATPases / metabolism
Substances
-
Interleukin-1
-
P2RX7 protein, human
-
P2rx7 protein, mouse
-
Receptors, Purinergic P2
-
Receptors, Purinergic P2X7
-
Regeneration and tolerance factor, human
-
Suppressor Factors, Immunologic
-
regeneration and tolerance factor
-
Vacuolar Proton-Translocating ATPases