Untranslated region haplotype in dysbindin gene: analysis in schizophrenia

J Neural Transm (Vienna). 2005 Sep;112(9):1263-7. doi: 10.1007/s00702-005-0338-9.

Abstract

Genome-scans performed in schizophrenia families have provided evidence for region 6p24-21 where variability may confer susceptibility to schizophrenia. Recent studies have implicated that gene DTNBP1 (dysbindin) in this region is strongly associated with schizophrenia. In a family based association study we investigated three markers located in the untranslated region of the DTNBP1 gene: rs909706, rs1047631 and rs742106. The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / genetics*
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Family Health
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Polymorphism, Genetic
  • Schizophrenia / genetics*
  • Untranslated Regions / genetics*

Substances

  • Carrier Proteins
  • DTNBP1 protein, human
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Untranslated Regions