Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice

Yukio Ago; Toshiya Harasawa; Soichi Itoh; Shigeo Nakamura; Akemichi Baba; Toshio Matsuda

doi:10.1016/j.ejphar.2005.08.011

Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice

Eur J Pharmacol. 2005 Sep 27;520(1-3):86-90. doi: 10.1016/j.ejphar.2005.08.011.

Authors

Yukio Ago¹, Toshiya Harasawa, Soichi Itoh, Shigeo Nakamura, Akemichi Baba, Toshio Matsuda

Affiliation

¹ Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

PMID: 16140294
DOI: 10.1016/j.ejphar.2005.08.011

Abstract

We have recently reported that coadministration of sulpiride, an antipsychotic drug, and fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, selectively increases in vivo dopamine release in the prefrontal cortex. This study examined the effects of coadministration of these drugs on duration of immobility in the tail suspension test using mice. Neither sulpiride (3 or 10 mg/kg) nor fluvoxamine (10 or 20 mg/kg) alone affected immobility time, whereas coadministration significantly reduced immobility time. WAY 100635, a 5-HT(1A) receptor antagonist, did not affect the effects of sulpiride and fluvoxamine coadministration, but reduced immobility time in combination with fluvoxamine (20 mg/kg). A high dose of fluvoxamine alone (60 mg/kg) also reduced immobility time. These results suggest that the antidepressant-like effects of fluvoxamine in combination with sulpiride or WAY 100635 in the tail suspension test are mediated by the activation of dopamine or 5-HT systems, respectively.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents, Second-Generation / administration & dosage
Antidepressive Agents, Second-Generation / pharmacology*
Dopamine Antagonists / administration & dosage
Dopamine Antagonists / pharmacology*
Dose-Response Relationship, Drug
Drug Combinations
Fluvoxamine / administration & dosage
Fluvoxamine / pharmacology*
Hindlimb Suspension
Male
Mice
Motor Activity / drug effects*
Piperazines / administration & dosage
Piperazines / pharmacology
Pyridines / administration & dosage
Pyridines / pharmacology
Selective Serotonin Reuptake Inhibitors / administration & dosage
Selective Serotonin Reuptake Inhibitors / pharmacology*
Serotonin Antagonists / pharmacology
Sulpiride / administration & dosage
Sulpiride / pharmacology*

Substances

Antidepressive Agents, Second-Generation
Dopamine Antagonists
Drug Combinations
Piperazines
Pyridines
Serotonin Antagonists
Serotonin Uptake Inhibitors
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
Sulpiride
Fluvoxamine